CentiServer
comprehensive centrality resource and server for centralities calculation version: 1.0.0

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The Centiserver on OMICTools

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Edge Weighted


Definition

Edge weight EW(u,v) use the following commonly used measures for evaluating the relationship between two proteins, whose nodes are connected by an edge in a PPI network and defined as:

EW(u,v) = NTE(u,v) * PCC(u,v) * GE(u,v)

where GE is GO functional similarity, PCC is co-expression levels among genes and NTE is the number of times that a PPI pair involved in PPI triangles.

Software

References

  • WANG, Y., SUN, H., DU, W., BLANZIERI, E., VIERO, G., XU, Y. & LIANG, Y. 2014. Identification of Essential Proteins Based on Ranking Edge-Weights in Protein-Protein Interaction Networks. PLoS ONE, 9, e108716.


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