Login The Centiserver on OMICTools 
LAC  Local Average ConnectivityBased MethodDefinition
Let N_{v} be the set of neighbors of node v. The subgraph G[N_{v}]
induced by N_{v} is named C_{v}. For a node w in C_{v}, distinguished from
its degree deg(ω) in G, its local connectivity in C_{v} is represented
as deg^{Cv} (w). It is obvious that each node i in G has only one deg(i),
but has different deg^{Cv} (i) with respect to different C_{v}. For each node
w∈N_{v}, its local connectivity deg^{Cv} (w) is defined as how many other
nodes in C_{v} it connects directly. Then, the local average connectivity
of a node v (LAC(v)) is defined as the average local connectivity of
its neighbors:
LAC(v) of a node v describes how close its neighbors are. Essentiality is, in many cases, a product
of complex function rather than an individual protein function.
The local average connectivity is such a local metric to determine
a protein’s essentiality based on the modular nature of protein
essentiality.
References
