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EGC  Edge clustering coefficient and Gene ontology information’s Combination methodDefinition
Gene ontology (GO) information is adopted as a
measure to evaluate the reliability of the edges in PPI network and a new algorithm
EGC is proposed to identify essential proteins by integrating the topological features
of the PPI network and the information of GO.
The essentiality of each protein u in PPI network is determined by: Here, t is a proportionality parameter which takes value in the range of 0 to 1, N_{u} is the set which contains all the neighbors of u. GO similarity The GO similarity between protein u and protein v is
Edge Clustering Coefficient The edge clustering coefficient of an edge (u, v), connecting node u and node v, can be defined by the following formula: Requirements
Undirected graph G=(V,E), GO database, parameter t and k.
SoftwareReferences
